What's the best way to get from Cincinnati to various major U.S. cities (e.g. DC, NYC, Chicago)?

There are a variety of ways to get to different major cities. You can take a flight from the Cincinnati/Northern Kentucky International Airport (located in Hebron, KY). CVG serves most major cities with direct and connecting flights. Delta is the major air carrier. You can also book a flight on the Ultimate Air Shuttle to cities such as Chicago, New York, Detroit, and Charlotte. The Ultimate Air Shuttle takes off from Lunken Airport in the eastern part of Cincinnati. More leisurely options of getting to your destination are by Amtrak train, taken from Union Terminal in the West End of Cincinnati, or by Greyhound Bus. If you want to go to Chicago, Indianapolis, or Columbus, Ohio, you can hop on the Megabus.