Which restaurant has the best burger in Cincinnati?

The Rookwood cooks a pretty tasty burger.

Also for a good basic burger at a reasonable price, I'd go with Five Guys. They've got one on Calhoun in The Heights and several other places.

One of my absolute favorite burger joints in Cincinnati is By Golly's up in Newtown. They offer a number of different burgers and toppings, all with delicious 10 oz. never-frozen beef patties. Their atmosphere is also really casual and relaxed, but still fun. They have a couple TVs showing different sporting events (a couple nights ago they were playing tennis, baseball, and Olympic try-outs) and on certain nights they host trivia, which I've heard is a blast. I just checked their calendar online and saw that they also have weekly open-mic nights and karaoke! If you're looking for a fun place to hang out, have a drink, watch the game, and eat an AMAZING burger, check out By Golly's...I highly recommend it.