In short, no there isn't.
While there a fair few trucking routes and industry in the outskirts of Yarraville (two suburbs away from Willi) and then pushing out into Brooklyn and then Sunshine, none of it seems to affect Williamstown. Williamstown is fortunate to be in a little corner with no real need for trucks to pass through it. There is a Ship building company (BAE Systems) in the heart, but that receives little traffic other than the employees that work there.
The busiest roads in Williamstown would be Melbourne Rd, Kororoit Creek Rd and Douglas Parade. Williamstown Rd being the major in road to the suburb and remains busy almost 24 hours a day. so I would avoid houses on that road or close by it.
Hope this has helped.